isirv

Q4 2023

Neuraminidase Inhibitors

Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo…read more

A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation…read more

Oseltamivir May or May Not Reduce Hospitalizations…read more

Baloxavir and Endonuclease Inhibitors

Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses…read more

Genomic Analysis of Influenza A and B Viruses Carrying Baloxavir Resistance-Associated Substitutions Serially Passaged in Human Epithelial Cells…read more

Pre-Clinical Evaluation of the Antiviral Activity of Epigalocatechin-3-Gallate, a Component of Green Tea, against Influenza A(H1N1)pdm Viruses…read more

New Drug Discovery & Virucides

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1…read more

Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors…read more

Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus…read more

Propylene glycol inactivates respiratory viruses and prevents airborne transmission…read more

Protective human antibodies against a conserved epitope in pre- and post- fusion influenza…read more

Clinical Trials & Case Studies

Rapid health technology assessment of the novel endonuclease inhibitor baloxavir for the treatment of influenza…read more

Prescription of anti-influenza drugs in Japan, 2014-2020: A retrospective study using open data from the national claims database…read more

Comparison of clinical efficacy and safety of baloxavir marboxil versus oseltamivir as the treatment for influenza virus infections: A systematic review and meta-analysis…read more

Prospective observational study of baloxavir marboxil in adults and adolescents with uncomplicated influenza from China…read more

Trends in Outpatient Influenza Antiviral Use Among Children and Adolescents in the United States…read more

Reviews

Influenza virus cell entry and targeted antiviral development…read more

Q2 AND Q3 2023

Neuraminidase Inhibitors

Efficacy of oseltamivir treatment in influenza virus-infected obese mice…read more

Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022…read more

Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Circulating Globally in 2022-2023…read more

Resistance profiles for the investigational neuraminidase inhibitor AV5080 in influenza A and B viruses…read more

Baloxavir and Endonuclease Inhibitors

Viral Fitness of Baloxavir-Resistant Recombinant Influenza B/Victoria- and B/Yamagata-like Viruses Harboring the I38T PA Change, In Vitro, Ex Vivo and in Guinea Pigs…read more

In Vivo Antiviral Activity of Baloxavir against PA/I38T-Substituted Influenza A Viruses at Clinically Relevant Doses…read more

PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor…read more

Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility…read more

A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023…read more

New Drug Discovery

FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants…read more

4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses…read more

Fc-Effector-Independent in vivo Activity of a Potent Influenza B Neuraminidase Broadly Neutralizing Antibody…read more

Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors…read more

Anti-influenza virus activities and mechanism of antrafenine analogues…read more

Discovery of a potent inhibitor targeting the cap-binding domain of the PB2 subunit of influenza RNA-dependent RNA polymerase…read more

Advanced virtual screening enables the discovery of a host-targeting and broad-spectrum antiviral agent…read more

Clinical Trials & Case Studies

Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study…read more

Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza: A Systematic Review and Meta-analysis…read more

Safety and Efficacy of Baloxavir Marboxil in Influenza-infected Children 5-11 Years of Age: A Post Hoc Analysis of a Phase 3 Study (miniSTONE-2)…read more

Early Fever Resolution in Early Childhood Influenza Treated with Baloxavir Marboxil: A Retrospective Study Compared to Those with Oseltamivir…read more

Oral Favipiravir Exposure and Pharmacodynamic Effects in Outpatient Adults with Acute Influenza…read more

Multicenter, randomized controlled, open label evaluation of the efficacy and safety of arbidol hydrochloride tablets in the treatment of influenza-like cases…read more

Arbidol: The current demand, strategies, and antiviral mechanisms…read more

Effectiveness of prolonged versus standard-course of oseltamivir in critically ill patients with severe influenza infection: A multicentre cohort study…read more

The combined effect of oseltamivir and favipiravir on influenza A virus evolution in patients hospitalized with severe influenza…read more

Reviews

The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs…read more

Q1 2023

Neuraminidase Inhibitors

Oseltamivir is protective for in-patient mortality in PCR confirmed influenza B and influenza A(H3N2) infections in an historic cohort of 1,048 patients hospitalised during the 2016-17 and 2017-18 influenza seasons…read more

Endonuclease and other Polymerase Inhibitors

Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors…read more

Prescription factors influencing baloxavir prescription during the 2018/2019 and 2019/2020 seasons: a administrative database study in Japan…read more

New Drug Discovery

Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses…read more

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication…read more

Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit…read more

Clinical Trials & Case Studies

Lessons from resistance analysis in clinical trials of IV zanamivir…read more

Comparative effectiveness of oseltamivir versus peramivir for hospitalized children (aged 0-5 years) with influenza infection…read more

Baloxavir safety and clinical and virologic outcomes in influenza virus-infected pediatric patients by age group: age-based pooled analysis of two pediatric studies conducted in Japan…read more

Influenza Antiviral Use in Patients Hospitalized With Laboratory-Confirmed Influenza in the United States, FluSurv-NET, 2015–2019…read more

Reviews

Influenza Treatment: Limitations of Antiviral Therapy and Advantages of Drug Combination Therapy…read more

Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA