The 5th isirv-AVG Conference entitled ‘Prevention and Treatment of RVIs: Antivirals, Traditional Therapies and Host-Directed Interventions’ will take place at the Regal East Asia Hotel, Shanghai, China, 14-16 June 2017 – Registration and Abstract Submission is now Open
GISAID-ISIRV-WHO Workshop on ‘Genetic Analyses of Influenza Viruses’, 29th August 2016, Northwestern University, Chicago
GISAID in collaboration with Northwestern University and the International Society for Influenza and Other Respiratory Virus Diseases (isirv) organised a training workshop on Genetic Analyses of Influenza Viruses at Northwestern University on 29 August 2016 in Chicago, following the IX Options for the Control of Influenza Conference, 24-28 August.
The purpose of the training workshop was to enable laboratories to contribute to and benefit from the extensive genetic and related data on influenza viruses, in relation to understanding the epidemiology of influenza, the evolution of the viruses and the emergence and spread of novel genetic and antigenic variants. Participants were instructed in the use of GISAID’s new EpiFlu™ 2.0 database, its novel features and advanced analysis tools for the identification (and display on phylogenetic trees) and interpretation (using FluSurver) of mutations underlying the evolution and antigenic variation of human and animal influenza viruses. Enhanced capacity to analyse and understand the relationships among influenza viruses is aimed at stimulating increased interaction between institutions involved in human and animal influenza surveillance and research. The programme included a combination of brief lectures, demonstrations and hands-on training – see attached.
The isirv Antiviral Group (isirv-AVG) was established as a special interest group of isirv at the time of merger in April 2011 of the former Neuraminidase Inhibitor Susceptibility Network (NISN) with isirv.
Its specific objectives are to promote understanding of the clinical use of antivirals against respiratory viruses, collate and provide up to date information on the emergence of antiviral resistance, and communicate expert commentary on preclinical and clinical development of potential novel/new antivirals in this area. Read More
Training Workshop on Genetic Analyses of Influenza Viruses, Hong Kong Polytechnic University, 21-22 November 2015
The 2-day training workshop on Genetic Analyses of Influenza Viruses, organised by isirv in conjunction with the GISAID Initiative, the WHO Global Influenza Surveillance and Response System and the Hong Kong Polytechnic University, was held at the Polytechnic University on 21-22 November 2015. The 33 trainees, from 24 countries, received instruction in the use of GISAID’s EpiFlu™ database and its new EpiFlu™ 2.0 platform, with its novel features and advanced analysis tools for the identification and interpretation of mutations underlying the evolution and antigenic variation of human and animal influenza viruses. Participants received financial support from the WHO, its Western Pacific regional office and isirv.
A summary report can be found here.
4th isirv Antiviral Group Conference, 2- 4 June 2015
The University of Texas at Austin, Texas, USA
The 4th AVG Conference held at the University of Texas on 2-4 June attracted a capacity audience of 200 registered participants. Against a backdrop of resistance to the licensed antivirals against influenza viruses and the lack of effective interventions against other respiratory viruses, the 3-day programme focused on the discovery and development of inhibitors of novel virus targets and key host cell factors. In relation to the development of monoclonal antibodies as therapeutics, the potential implications of antibody-dependent enhancement of disease were also addressed. The ten sessions covered the whole gamut of steps from structural and molecular biology to clinical studies, and included consideration of clinical trial endpoints and regulatory issues.
The inaugural ‘live’ twitter coverage was a very successful innovation. More than 160 tweets under the hashtag “#isirvAVG2015” were posted and the number of twitter “followers” of isirv-AVG doubled. The social media coverage not only showcased the speakers but also reached out to the wider scientific community. The "Meeting Report" can be foundhere
The Workshop on Next Generation Sequencing (NGS) of Viruses, organised by the isirv-AVG in conjunction with GISAID and the PREDEMICS Consortium, held at the Institut Pasteur, Paris on 20-21 May 2015 attracted 117 registered participants. The 2-day expert workshop covered various aspects of current sequencing technologies, data processing and analysis of data for a variety of RNA viruses, with a particular focus on quality and interpretation of results and the significance and use of NGS data for public and animal health.
A summary can be found here
Resistance to mutant group 2 influenza virus neuraminidases of an oseltamivir-zanamivir hybrid inhibitor
Using crystallography analysis, the molecular mechanism responsible for the multidrug resistance conferred by E119V/I222L dual mutations in the neuraminidase of influenza A(H3N2) was elucidated. This multi-drug resistant A(H3N2) variant can be effectively inhibited by a novel oseltamivir-zanamivir hybrid inhibitor, MS-257, owning to the increased stability between the inhibitor and the active site in the neuraminidase…read more
A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro
RO-7, a novel influenza virus PA protein inhibitor, possessed antiviral activity against multiple influenza A and B viruses in MDCK cells, and cleavage of a PA protein nucleic acid substrate in the nanomolar range…read more
JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses
As demonstrated in human macrophage cell line, JNJ-872 (formally known as VX-787), an inhibitor of the cap-snatching domain of influenza polymerase basic 2 protein, can inhibit influenza virus replication and do not interfere with the antiviral responses of the innate immune system… read more
Peramivir injection in the treatment of acute influenza: A review of the literature
A review on the mechanism of actions, pharmacology, clinical efficacy, safety profile and the outlook on the use of peramivir in influenza treatment… read more
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