isirv

	2024		2023		2022		2021		2019

Q3 2024

Neuraminidase Inhibitors

Genotypic and phenotypic susceptibility of emerging avian influenza A viruses to neuraminidase and cap-dependent endonuclease inhibitors…read more

Occurrence and environmental fate of anti-influenza drugs in a subcatchment of the Yodo River Basin, Japan…read more

The Synergistic Effect of Baloxavir and Neuraminidase Inhibitors against Influenza Viruses In Vitro…read more

Discovery of new quinoline derivatives bearing 1-aryl-1,2,3-triazole motif as influenza H1N1 virus neuraminidase inhibitors…read more

 

BALOXAVIR AND ENDONCULEASE INHIBTIORS

Detection of influenza A(H3N2) viruses with polymerase acidic subunit substitutions after and prior to baloxavir marboxil treatment during the 2022–2023 influenza season in Japan…read more

High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro…read more

Comparison of the Effectiveness of Baloxavir and Oseltamivir in Outpatients With Influenza B…read more

Real-world effectiveness and safety of Baloxavir Marboxil or Oseltamivir in outpatients with uncomplicated influenza A: an ambispective, observational, multi-center study…read more

Safety and effectiveness of baloxavir marboxil and oseltamivir for influenza in children: a real-world retrospective study in China…read more

Cost-Effectiveness of Baloxavir Marboxil Versus Oseltamivir or no Treatment for the Management of Influenza in the United States…read more

Baloxavir Resistance Markers in Influenza A and B Viruses in the Americas…read more

 

NEW DRUG DISCOVERY

hnRNPAB inhibits Influenza A virus infection by disturbing polymerase activity…read more

Glycopolymer with Sulfated Fucose and 6'-Sialyllactose as a Dual-Targeted Inhibitor on Resistant Influenza A Virus Strains…read more

Design and synthesis of 7-membered lactam fused hydroxypyridinones as potent metal binding pharmacophores (MBPs) for inhibiting influenza virus PAN endonuclease…read more

Chemoenzymatic synthesis of sialyl-α2,3-lactoside-functionalized BSA conjugate inhibits influenza infection…read more

Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA-PB1 Subunits Interaction…read more

An N-terminal heptad repeat trimer-based peptide fusion inhibitor exhibits potent anti-H1N1 activity…read more

Dual neutralization of influenza virus hemagglutinin and neuraminidase by a bispecific antibody leads to improved antiviral activity…read more

Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization…read more

PEG-SeNPs as therapeutic agents inhibiting apoptosis and inflammation of cells infected with H1N1 influenza A virus…read more

LINC01197 inhibits influenza A virus replication by serving as a PABPC1 decoy…read more

 

CLINICAL TRIALS AND MODELING; CASE STUDIES

Evaluating the Public Health and Health Economic Impacts of Baloxavir Marboxil and Oseltamivir for Influenza Pandemic Control in China: A Cost-Effectiveness Analysis Using a Linked Dynamic Transmission-Economic Evaluation Model…read more

The real-world safety of oseltamivir and baloxavir marboxil in children: a disproportionality analysis of the FDA adverse event reporting system…read more

Zanamivir and baloxavir combination to cure persistent influenza and coronavirus infections after hematopoietic stem cell transplant…read more

 

REVIEWS AND COMMENTARY

Antivirals for post-exposure prophylaxis of influenza: a systematic review and network meta-analysis…read more

Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction…read more

 

Q2 2024

Neuraminidase Inhibitors

Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023-February 2024…read more

Global emergence of neuraminidase inhibitor-resistant influenza A(H1N1)pdm09 viruses with I223V and S247N mutations: implications for antiviral resistance monitoring…read more

Impact of the H274Y Substitution on N1, N4, N5, and N8 Neuraminidase Enzymatic Properties and Expression in Reverse Genetic Influenza A Viruses…read more

Discovery and synthesis of novel benzoylhydrazone neuraminidase inhibitors…read more

Low antiviral resistance in Influenza A and B viruses isolated in Mexico from 2010 to 2023…read more

 

Baloxavir and Endonuclease Inhibitors

Comparative Effectiveness of Baloxavir Marboxil and Oseltamivir Treatment in Reducing Household Transmission of Influenza: A Post Hoc Analysis of the BLOCKSTONE Trial…read more

Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: Biological evaluation of in vitro and in vivo…read more

 

New Drug Discovery

Antiviral activity of adenoviral vector expressing human interferon lambda-4 against influenza virus…read more

Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract…read more

Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry…read more

Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways…read more

Spleen tyrosine kinase inhibitor R406 has both antiviral and anti-inflammatory effects on severe influenza A infection…read more

Host-directed antiviral strategy: The potential of SYK inhibitor R406 against influenza A virus infection…read more

Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core…read more

Broadly protective bispecific antibodies that simultaneously target influenza virus hemagglutinin and neuraminidase…read more

 

Clinical Trials and Modelling, Case Studies

Study on the clinical efficacy and safety of baloxavir marboxil tablets in the treatment of influenza A…read more

Pharmacoeconomic study of anti-influenza virus drugs in Japan based on a network meta-analysis…read more

A cost-effectiveness analysis of reduced viral transmission with baloxavir marboxil versus oseltamivir or no treatment for seasonal and pandemic influenza management in the United Kingdom…read more

Duration of fever in children infected with influenza A(H1N1)pdm09, A(H3N2) or B virus and treated with baloxavir marboxil, oseltamivir, laninamivir, or zanamivir in Japan during the 2012-2013 and 2019-2020 influenza seasons…read more

A noninferiority randomized open-label pilot study of 3- versus 7-day influenza postexposure prophylaxis with oseltamivir in hospitalized children…read more

 

Reviews & Commentary

Preclinical animal models to evaluate therapeutic antiviral antibodies…read more

 

Q1 2024

Neuraminidase Inhibitors

Inhibiting influenza virus transmission using a broadly acting neuraminidase that targets host sialic acids in the upper respiratory tract…read more

Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo…read more

 

Baloxavir and Endonuclease Inhibitors

Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants…read more

Baloxavir marboxil use for critical human infection of avian influenza A H5N6 virus…read more

The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir…read more

Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics…read more

Antivirals to prepare for surges in influenza cases: an economic evaluation of baloxavir marboxil for the Netherlands…read more

 

New Drug Discovery & Virucides

Identification of dihydroorotate dehydrogenase inhibitor, vidofludimus, as a potent and novel inhibitor for influenza virus…read more

Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results…read more

Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo…read more

Discovery of cyperenoic acid as a potent and novel entry inhibitor of influenza A virus…read more

 

Clinical Trials & Case Studies

Outpacing antiviral resistance: new treatments for influenza virus infection…read more

Household Influenza Transmission and Healthcare Resource Utilization Among Patients Treated with Baloxavir vs Oseltamivir: A United States Outpatient Prospective Survey…read more

Clinical outcomes of baloxavir versus oseltamivir in immunocompromised patients…read more

Safety and efficacy of onradivir in adults with acute uncomplicated influenza A infection: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial…read more

Virological and clinical outcomes in outpatients treated with baloxavir or neuraminidase inhibitors for A(H3N2) influenza: A multicenter study of the 2022-2023 season…read more

Efficacy of Pharmacotherapy for Seasonal Influenza in Young and Middle-aged Adults: A Systematic Review and Network Meta-analysis…read more

 

Reviews & Commentary

Commentary: Randomized, placebo-controlled trial of antiviral treatment in patients hospitalized for influenza…read more

 

Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA