isirv Antiviral Group
News
2023 | 2022 | 2021 | 2019 | |||||||||||
Q1 2023
Neuraminidase Inhibitors
Oseltamivir is protective for in-patient mortality in PCR confirmed influenza B and influenza A(H3N2) infections in an historic cohort of 1,048 patients hospitalised during the 2016-17 and 2017-18 influenza seasons…read more
Endonuclease and other Polymerase Inhibitors
Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors…read more
Prescription factors influencing baloxavir prescription during the 2018/2019 and 2019/2020 seasons: a administrative database study in Japan…read more
New Drug Discovery
Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses…read more
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication…read more
Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit…read more
Clinical Trials & Case Studies
Lessons from resistance analysis in clinical trials of IV zanamivir…read more
Comparative effectiveness of oseltamivir versus peramivir for hospitalized children (aged 0-5 years) with influenza infection…read more
Baloxavir safety and clinical and virologic outcomes in influenza virus-infected pediatric patients by age group: age-based pooled analysis of two pediatric studies conducted in Japan…read more
Influenza Antiviral Use in Patients Hospitalized With Laboratory-Confirmed Influenza in the United States, FluSurv-NET, 2015–2019…read more
Reviews
Influenza Treatment: Limitations of Antiviral Therapy and Advantages of Drug Combination Therapy…read more
Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA