isirv

Q4 2022

Endonuclease Inhibitors

Effect of E23G/K, F36V, N37T, E119D, and E199G polymerase acidic protein substitutions on the replication and baloxavir susceptibility of influenza B viruses…read more

Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential…read more

Identification of N- and C-3-Modified Laudanosoline Derivatives as Novel Influenza PAN Endonuclease Inhibitors…read more

New Drug Discovery

Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106…read more

Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction…read more

Novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine Derivatives: Synthesis, Anti-Viral In Vitro Study and Target Validation Activity…read more

Clinical Trials & Case Studies

Favipiravir Treatment of Uncomplicated Influenza in Adults: Results of Two Phase 3, Randomized, Double-Blind, Placebo-Controlled Trials…read more

Methods

An optimized cell-based assay to assess influenza virus replication by measuring neuraminidase activity and its applications for virological surveillance…read more

Reviews

Nucleoside analogs for management of respiratory virus infections: mechanism of action and clinical efficacy…read more

Influenza antivirals and their role in pandemic preparedness…read more

Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA

Q3 2022

Neuraminidase Inhibitors

Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs…read more

Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions…read more

Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution…read more

Baloxavir Marboxil

Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission…read more

Effect of Baloxavir and Oseltamivir in Combination on Infection with Influenza Viruses with PA/I38T or PA/E23K Substitutions in the Ferret Model…read more

Assessing the fitness of a dual-antiviral drug resistant human influenza virus in the ferret model… read more

New Drug Discovery

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins… read more

An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA… read more

Clinical Trials & Case Studies

Methods

Assays for Determining the Sialidase Activity of Influenza Viruses and Monitoring Influenza Virus Susceptibility to Neuraminidase Inhibitors…read more

Preparation of Recombinant PA Endonuclease Domain Protein of Influenza A Virus and Its Application for Glycobiology Research…read more

Reviews

Influenza…read more

Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA

Q2 2022

Neuraminidase Inhibitors

Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors…read more

Frequency and distribution of H1N1 influenza A viruses with oseltamivir-resistant mutations worldwide before and after the 2009 pandemic…read more

Baloxavir Marboxil (Keywords: Influenza baloxavir; baloxavir marboxil)

Pleiotropic Effects of Influenza H1, H3, and B Baloxavir-Resistant Substitutions on Replication, Sensitivity to Baloxavir, and Interferon Expression…read more

Duration of fever and symptoms in influenza-infected children treated with baloxavir marboxil during the 2019-2020 season in Japan and detection of influenza virus with the PA E23K substitution…read more

A novel E198K substitution in the PA gene of influenza A virus with reduced susceptibility to baloxavir acid… read more

New Drug Discovery

Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors… read more

Reviews

Influenza antivirals and animal models…read more

Preclinical and clinical developments for combination treatment of influenza… read more

Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA

Q1 2022

New Drug Discovery

Anti-influenza Virus Activity of Methylthio-Formycin Distinct From That of T-705…read more

Clinical Trials & Case Studies

Comparative effectiveness of neuraminidase inhibitors in patients with influenza: A systematic review and network meta-analysis…read more

Reviews

Antivirals Targeting the Neuraminidase…read more

From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus…read more

Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA